Grey Bruce OPP say one person was airlifted after a crash on Bruce Road 8 between Hepworth and Sauble.
They say on Wednesday afternoon officers responded to a collision between two SUVs.
One driver was airlifted to a trauma centre where OPP say their injuries were deemed non life-threatening.
Bruce Road 8 was closed between Municipal Road and Bruce Road 14 for several hours. It reopened Wednesday evening.