The Grey Bruce Health Unit reported eight new cases of COVID-19 on Saturday.
Officials say residents of Southgate, South Bruce, Huron Kinloss and Arran-Elderslie all tested positive.
They say the number of active cases across the region climbed to 53 after new cases outpaced the four new resolved cases.
No outbreaks have been reported at hospitals, long-term care homes, schools or childcare centres.
To date, there have been five deaths related to the virus across Grey Bruce.
Officials have given out 78-thousand doses of vaccines since they started the vaccination process.