Environment Canada has issued a Snowsquall Warning for Grey, Bruce, Simcoe, Huron, Perth and Dufferin Counties as the blustery winter weather continues.
Officials say the region may receive upwards of 20 centimetre of snowfall prior to your Monday commute.
Snow-squalls also bring wind gusts of up to 80 kilometres per hour, along with near zero visibility in the heavy snow and blowing snow.
Road conditions vary throughout the area from bare and wet to snowcovered with very slippery sections on secondary routes, in town and in City routes and sideroads.
Provincial highways are described as snow-covered and slushy to bare and wet.
Highway 21 is closed from Port Elgin to Southampton to Springmount.
Highway 23 is closed from Listowel to Mitchell and further to Elginfield Road due to poor driving conditions.
One motorist tells Bayshore Broadcasting News that Highway 21 is treacherous along the Lake Huron shoreline.
There was also a serious crash on Highway 6 and 10 at Rockford on Sunday night.
Grey Road 4 is closed from Flesherton to Grey Road 124 due to zero visibility.
Dufferin Road 124 has also been closed by the OPP due to treacherous driving conditions.
Paramedics across the region have responded to numerous collisions.
There have been several collisions reported on Highway 400 in the Barrie area as well.
Police are urging motorists to drive for the conditions and slow down.
The snow-squalls and poor driving conditions are expected to continue on Monday, with an additional 10 to 15 centimetre of snowfall before the storm tapers off.