The Perth District Health Unit says a cow in Ellice Ward has tested positive for the Arctic fox strain of rabies.
Officials with Ontario's Ministry of Agriculture, Food and Rural Affairs say it's the first time the strain has surfaced in the southern part of the province since 2012.
But lead veterinarian Maureen Anderson says it's not unheard of for a rabies strain to resurface after being dormant for some time.
Anderson says animals who came into contact with the affected calf have been placed in confinement and there are no other suspected rabies cases in the area at the moment.
Both Anderson and the Perth Health Unit say this case is not related to a recent outbreak of raccoon-strain rabies in Hamilton.
A dozen raccoons in that area have tested positive since December, marking the first time since 2005 that the strain has appeared in the province.